منابع مشابه
Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process.
Vanillyl-alcohol oxidase (VAO; EC 1.1.3.38) contains a covalently 8alpha-histidyl bound FAD, which represents the most frequently encountered covalent flavin-protein linkage. To elucidate the mechanism by which VAO covalently incorporates the FAD cofactor, apo VAO was produced by using a riboflavin auxotrophic Escherichia coli strain. Incubation of apo VAO with FAD resulted in full restoration ...
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for the regulation of sleep-wakefulness (Urbano et al., 2012). From the evolutionary point of view it can be assumed that the primitive brain had auto-regulatory oscillations between awake-like and sleep-like states (Cirelli, 2009). As evolution progressed, and as the brainstem, diencephalon, and neocortex were formed, they also became part of the oscillating network. Prior activity in the netw...
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Nitros(yl)ation is a widespread protein modification that occurs during many physiological and pathological processes. It can alter both the activity and function of a protein. Nitric oxide (( small middle dot)NO) has been implicated in this process, but its mechanism remained uncertain. ( small middle dot)NO is unable to react with nucleophiles under oxygen-free conditions, suggesting that its...
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The Gillespie Algorithm is used to simulate a prion model so that the kinetics of the prions may be observed. The model is purely autocatalytic, that is, there is no fusion or fission of the infectious units. There is only conversion of PrP C into prions through a mechanism comprised of attaching PrP C to a PrP Sc p-mer, domain swapping, and splitting. It is well known that any model of an infe...
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1. Dietrich, L.E., Teal, T.K., Price-Whelan, A. & Newman, D.K. Science 321, 1203–1206 (2008). 2. Pomposiello, P.J. & Demple, B. Adv. Microb. Physiol. 46, 319–341 (2002). 3. Pollack, M. in Principles and Practice of Infectious Diseases (eds. Mandell, G. L., Bennett, J. E. & Dolin, R.) 2310–2335 (Churchill Livingstone, New York, 2000). 4. Pomposiello, P.J., Bennik, M.H. & Demple, B. J. Bacteriol....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1916
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)87495-6